Ectoderm to mesoderm transition by down-regulation of actomyosin contractility

Regulation of tissue morphodynamics: an important role for actomyosin contractility.

Forces arising from contractile actomyosin filaments help shape tissue form during morphogenesis. Developmental events that result from actomyosin contractility include tissue elongation, bending, budding, and collective migration. Here, we highlight recent insights into these morphogenetic processes from the perspective of actomyosin contractility as a key regulator. Emphasis is placed on a ra...

Conversion of Presumptive Ectoderm to Mesoderm in the Chick

THE greater part of descriptive embryology is based on the concept of the three germ-layers—ectoderm, mesoderm and endoderm. As we acquire more information about the physiology of development, it is natural to ask whether the same concept is as fundamental for a consideration of individual development as it is for comparative morphology. The investigations on the Amphibia have already provided ...

Active contractility in actomyosin networks.

Contractile forces are essential for many developmental processes involving cell shape change and tissue deformation. Recent experiments on reconstituted actomyosin networks, the major component of the contractile machinery, have shown that active contractility occurs above a threshold motor concentration and within a window of cross-link concentration. We present a microscopic dynamic model th...

Regulation of thickness of actomyosin cortex in well-spread cells by contractility and spread area

Down Regulation of DHFR Promoter Activity by PML Transcription Repressor